用Novavax的蛋白质疫苗进行的三次免疫接种增加了抗体宽度,并提供了对SARS-CoV-2的持久保护
Klara Lenart1,2,3, Rodrigo Arcoverde Cerveira1,2,3, Fredrika Hellgren1,2,3
1Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
NPJ vaccines
|January 20, 2024
概括
使用Matrix-M辅助剂的Novavax COVID-19疫苗的第三剂量增强了免疫反应,并提供了对包括Omicron在内的SARS-CoV-2变种的持久保护.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 对Novavax的NVX-CoV2373刺蛋白抗SARS-CoV-2疫苗的免疫反应尚未完全理解.
- 辅助疫苗可能会引起局部免疫反应.
研究的目的:
- 在 rhesus macaques 中研究更新的 Novavax 疫苗第三剂的免疫反应和保护疗效.
- 评估增强剂对抗体标位,宽度和B细胞反应的影响.
主要方法:
- rhesus 被免疫使用 Matrix-M 辅助的 NVX-CoV2373 疫苗.
- 在初级免疫接种7个月后,第三剂基于Gamma (P.1) 变种的疫苗被给予.
- 动物受到SARS-CoV-2菌株 (WA-1或P.1) 的挑战.
主要成果:
- 第三剂量显著提高了抗抗体标位和宽度,包括对Omicron变种的中和.
- 助推剂扩大了B细胞记忆池,增加了体质突变,并改善了抗体激发性.
- 接种疫苗的动物控制了WA-1和P.1的SARS-CoV-2感染,通过肺免疫反应介导的持久保护.
结论:
- 用辅助剂,低剂量重组蛋白疫苗进行第三次免疫接种显著改善了B细胞反应质量和抗体范围.
- 辅助剂量提供了对SARS-CoV-2挑战的持久保护.
- 这一策略增强了免疫记忆,并保护对进化的病毒菌株.
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