对非生物人工肝脏DPMAES支持系统的临床研究,用于乙型肝炎相关的急性至慢性肝衰竭
Xianwen Cheng1, Yanrong Zhan2, YaoShun Liu3
1Ankang Hospital of Traditional Chinese Medicine, Ankang, 725000, Shaanxi, China. 807497738@qq.com.
Scientific reports
|January 20, 2024
概括
双等离子分子吸附交换系统 (DPMAES) 通过减轻细胞因子风暴,显著改善了与乙型肝炎病毒相关的急性至慢性肝衰竭 (HBV-ACLF) 患者的生存率和临床结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 与乙型肝炎病毒相关的急性至慢性肝衰竭 (HBV-ACLF) 是一种严重的临床疾病,其特点是死亡率高.
- 细胞因子风暴在HBV-ACLF的发病和进展中起着至关重要的作用.
- 需要有效的治疗策略来改善HBV-ACLF患者的治疗结果.
研究的目的:
- 评估双重血分子吸附交换系统 (DPMAES) 在HBV-ACLF患者的临床疗效.
- 评估DPMAES对减轻HBV-ACLF中的细胞因子风暴的影响.
- 在治疗HBV-ACLF时,将DPMAES与血交换 (PE) 进行比较.
主要方法:
- 总共有60名HBV-ACLF患者被纳入.
- 30名患者接受DPMAES治疗 (观察组).
- 30名患者接受了血交换 (PE) 治疗 (控制组).
主要成果:
- 与PE相比,DPMAES治疗显著提高了90天生存率18%.
- DPMAES导致总 bilirubin 和炎症性细胞因子 (IL-6,prokalcitonin) 的显著减少.
- DPMAES比PE更有效地改善了白蛋白和血小板水平,保持了血小板稳定性,并最大限度地减少了白蛋白消耗.
结论:
- 在快速降低总胆红素,改善凝血功能和减轻HBV-ACLF中的细胞因子风暴方面,DPMAES比PE更有效.
- 在HBV-ACLF患者中,DPMAES显著改善了90天的生存率和临床结果.
- DPMAES为管理HBV-ACLF及其相关的细胞因子风暴提供了一个有前途的治疗选择.
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