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Updated: Jul 5, 2025

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
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Published on: February 24, 2014

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固有的基因组不稳定性是三症21相关的骨髓性恶性瘤的基础

Chun-Chin Chen1, Rebecca E Silberman2,3, Duanduan Ma4

  • 1Stem Cell Transplantation Program, Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.

Leukemia
|January 20, 2024
PubMed
概括

患有三症21 (T21) 个体在血液细胞中增加了基因组不稳定性,促进导致急性髓性白血病 (AML) 的突变. 这种不稳定性,加剧了GATA1s突变,驱动T21中的骨髓质恶性瘤.

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