通过功能性心声学评估败血症新生儿的血液动力学功能障碍:系统性审查
Flaminia Pugnaloni1, Domenico Umberto De Rose2,3, Florian Kipfmueller4
1Research Area of Fetal, Neonatal, and Cardiological Sciences, Bambino Gesù Children Hospital, IRCCS, 00165, Rome, Italy.
Pediatric research
|January 20, 2024
概括
新生儿科医生进行的心声回声学 (NPE) 可以识别败血症新生儿的显著血液动力学变化,包括肺高血压和腹功能障碍. 更广泛的NPE使用可以改善定制的,基于血液动力学的治疗策略,以获得更好的患者结果.
科学领域:
- 新生儿医学 新生儿医学
- 心脏病学 心脏病学
- 儿科重症监护中心儿童重症监护中心
背景情况:
- 新生儿败血症是新生儿重症监护室死亡的主要原因.
- 在败血症中早期发现心血管功能障碍至关重要.
- 新生儿科医生进行的心声回声扫描 (NPE) 显示出早期败血症诊断的前景.
研究的目的:
- 系统地审查患有败血症的新生儿的心声学发现.
- 评估NPE在识别败血症相关心血管变化的有用性.
- 为未来的新生儿败血症回声心脏学研究奠定基础.
主要方法:
- 按照PRISMA指南进行系统审查.
- 包括前性观察性,横截面,病例控制和队列研究.
- 使用纽卡斯尔-太华尺度和描述性分析进行质量评估.
主要成果:
- 包括12项涉及438名败血症新生儿和232名对照者的研究.
- 败血症新生儿患肺高血压或左心室扩张功能障碍的风险增加.
- 在败血症新生儿中观察到具有更高心脏输出的热冲击生理学.
结论:
- 败血症新生儿通过NPE表现出显著的,可识别的血液动力学变化.
- 研究定义的异质性和有限的样本大小被注意到.
- 建议针对量身定制的,基于血液动力学的治疗策略进行更广泛的NPE实施.
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