脂肪组织衍生代谢物风险评分和南亚人2型糖尿病风险
Meghana D Gadgil1, Jing Cheng2, David M Herrington3
1Division of General Internal Medicine, Department of Medicine, University of California, San Francisco School of Medicine, 1545 Divisadero Street, Suite 320, San Francisco, CA, 94143, USA. meghana.gadgil@ucsf.edu.
南亚人面临更高的2型糖尿病 (T2D) 风险. 异位脂肪的新代谢物风险评分,特别是肝硬化和内脏脂肪,强烈预测事件T2D,独立于体重指数. 这些分数可以改善风险分层.
科学领域:
- 代谢学 代谢学 代谢学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 与其他族群相比,南亚人患2型糖尿病 (T2D) 的风险较高.
- 宫外脂肪,包括肝硬化和内脏脂肪,是导致这种风险增加的潜在因素.
- 这项研究旨在制定基于代谢物的异位脂肪的风险评分,并评估它们与南亚人发生的T2D的关联.
研究的目的:
- 为了获得肝硬化和内脏脂肪的代谢物风险评分.
- 评估这些代谢物风险得分与南亚队列中的2型糖尿病 (T2D) 发病率之间的关联.
- 为了确定这些关联是否独立于测量的脂肪性持续存在.
主要方法:
- 利用了来自美国南亚人动脉样硬化调解者 (MASALA) 队列研究的550名参与者的数据.
- 通过计算机断层扫描评估肝脏衰减和内脏脂肪区域.
- 采用弹性净调整线性回归来推导代谢物风险得分 (MET-Liver和MET-Visc) 和后勤回归来与事件T2D关联得分,调整共变量.
主要成果:
- 该研究包括550名参与者 (平均年龄55岁,女性36%,BMI为25公斤/米2).
- 代谢物风险得分,MET-Liver (OR 2.04) 和MET-Visc (OR 2.80),与发生T2D的更高几率显著相关.
- 这些关联在调整为测量脂肪度后仍然显著.
结论:
- 肝脏内脂肪和内脏脂肪的代谢物风险评分与南亚人发生的T2D严重相关.
- 这些关联独立于测量脂肪度,表明具有独特的预测价值.
- 这些生物标志物可能会增强临床前代谢异常和T2D的风险分层.
更多相关视频
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Obesity
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
