不同非药物类安慰剂治疗对偏头痛预防的影响:随机对照试验的网络元分析
Yan-Bing Huang1, Lu Yuan1, Xin-Yu Xiao1
1The Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Wenjiang District, Chengdu, 611100, China.
Acta neurologica Belgica
|January 20, 2024
概括
假针在偏头痛预防方面表现出最显著的安慰剂效应,在减少偏头痛发作和头痛频率方面超过了其他非药物干预措施. 这凸显了它在评估偏头痛治疗中的重要性.
科学领域:
- 神经学 神经学
- 临床试验 临床试验
- 基于证据的医学基于证据的医学.
背景情况:
- 控制安慰剂对于评估偏头痛预防干预的有效性至关重要.
- 了解不同的安慰剂效应是比较预防性治疗的关键.
研究的目的:
- 评估各种非药理性安慰剂类型对偏头痛患者结局的影响.
- 为了比较不同假冒干预措施在偏头痛预防中的有效性.
主要方法:
- 在PubMed,Embase,Cochrane和Web of Science数据库进行系统搜索,截至2023年6月19日.
- 包括使用模拟针,认知行为疗法 (CBT),非侵入性迷你神经刺激 (nVNS),重复性跨磁刺激 (rTMS) 或跨直流刺激 (tDCS) 的偏头痛随机对照试验 (RCT).
- 网络元分析使用平均差异来比较原发作 (偏头痛天) 和二次结果 (偏头痛发作,头痛天/频率,响应率) 的安慰剂效应.
主要成果:
- 分析了50项试验,包括4880名受试者;其中27项具有偏差低风险.
- 假冒rTMS和假冒tDCS在减少偏头痛天数方面显示出最佳的,类似的效果.
- 假在减少偏头痛发作和头痛频率方面最有效.
- 与其他安慰剂对照组相比,Sham rTMS显著减少了头痛天数.
结论:
- 假针在偏头痛预防中表现出最强的安慰剂效应.
- 在评估偏头痛管理中的治疗疗效时,必须考虑假针的显著安慰剂效应.
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