高强度间歇性训练改善了甲状腺素诱导的急性肺损伤
Mohammad Amin Rajizadeh1,2,3, Mahdiyeh Haj Hosseini3,4, Mina Bahrami3,4
1Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
BMC pulmonary medicine
|January 20, 2024
概括
高强度间歇性训练 (HIIT) 通过减少炎症和氧化应激,有效地对抗甲醇引起的肺损伤. 这种运动干预措施在预防和治疗药物诱导的肺损伤方面表现有前途.
科学领域:
- 肺部医学 肺部医学
- 运动生理学 运动生理学
- 毒理学 毒理学 毒理学
背景情况:
- 甲甲酸 (MTX) 是一种广泛使用的化疗和免疫抑制剂.
- MTX主要通过炎症和氧化应激诱导肺损伤.
- 高强度间歇性训练 (HIIT) 具有已知的抗氧化和抗炎性质.
研究的目的:
- 在大鼠模型中研究HIIT在减轻MTX诱导的肺损伤方面的疗效.
- 评估HIIT对氧化应激标志物,炎症细胞因子和肺组织病理学的影响.
主要方法:
- 七十只雄性Wistar大鼠被分配到五个组:控制,HIIT,急性肺损伤 (ALI),HIIT+ALI (治疗前) 和ALI+HIIT (治疗后).
- 进行HIIT干预,持续8周.
- 评估的参数包括氧化应激标志物 (MDA,TAC,SOD,GPx),炎症标志物 (MPO,TNF-α,IL-10),免疫细胞转录因子 (T-bet,GATA3,FOXP3),肺水含量,毛细血管透性,细胞亡 (Caspase-3),以及组织病理学.
主要成果:
- 使用MTX显著增加了促炎和氧化应激标志物 (TNF-α,MPO,GATA3,Caspase-3) 和肺.
- MTX治疗降低了抗氧化能力和抗炎性标志物 (TAC,SOD,GPx,IL-10,T-bet,FOXP3) 的作用.
- HIIT (治疗前和治疗后) 通过减少氧化和炎症因素,,改善组织病理结果,减轻MTX诱导的肺损伤,同时增强抗氧化和抗炎标志物.
结论:
- 在老鼠中,HIIT显示出重要的保护性和治疗性潜力,可以预防甲状腺素诱导的肺损伤.
- HIIT的好处归因于它抵消氧化应激和炎症的能力.
- 对于患有MTX相关的肺毒性患者来说,HIIT可以作为一种有价值的补充疗法.
关键词:
急性肺损伤是什么?急性肺损伤是什么?高强度间歇性训练是一种高强度的间歇性训练.炎症因素 炎症因素甲基甲酸二醇的使用方法穆罕默德·阿明·拉吉扎德,Mahdiyeh Haj Hosseini,米娜·巴赫拉米,Faegheh Bahri和Fahimeh Rostamabadi同样作为第一作者贡献了自己的作品.氧化应激是一种氧化应激.治疗效果 治疗效果 治疗效果更多相关视频
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