洞察到雌激素对口腔健康和COVID-19中的微生物组的影响
Rubén Alberto Bayardo-González1, Marcela Peña-Rodríguez2, Ana Laura Pereira-Suárez3
1Programa de Doctorado en Microbiología Médica, Centro Universitario de Ciencias de La Salud (CUCS) Universidad de Guadalajara, Guadalajara, Jalisco, México.
BMC microbiology
|January 20, 2024
概括
这项研究表明,绝经后的女性和患有COVID-19的男性表现出较差的口腔健康,这与较低的ACE2表达和雌激素水平有关. 口腔失生症可能导致严重的COVID-19进展.
科学领域:
- 口腔健康研究 口腔健康研究
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 在全球范围内,COVID-19已经造成数百万人的死亡,男性患病更严重.
- 女性的荷尔蒙因素可能会对炎症和ACE2表达提供保护.
- 口腔健康和微生物群在呼吸道病毒感染中的作用仍未得到充分研究.
研究的目的:
- 为了研究口腔健康,病毒载荷,ACE2表达和唾液因子在绝经前妇女,绝经后妇女和男性的COVID-19之间的关系.
主要方法:
- 在20名绝经前妇女,18名绝经后妇女和22名患有COVID-19的男性中,分析了口腔健康状况,病毒载荷,语言ACE2表达,唾液微生物组,雌激素和细胞因子.
主要成果:
- 与绝经前妇女相比,绝经后妇女表现出较低的舌头ACE2表达.
- 唾液雌激素水平与病毒载量负相关.
- 口腔微生物组分析揭示了与口腔健康状况和病毒载量相关的独特特征,包括高病毒载量组中的Prevotella和Porphyromonas.
结论:
- 绝经后妇女和患有COVID-19的男性口腔健康不佳可能与较低的ACE2表达,雌激素减少和口腔失生症有关,可能导致疾病严重程度.
- 需要进一步的功能研究来阐明这些关系.
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