脑源性神经营养因子血清水平作为吸毒海洛因依赖中戒断的候选生物标志物
Enam Alhagh Charkhat Gorgich1, Mohammad Gol Rigi2, Hamed Fanaei3,4
1Department of Anatomy, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Substance abuse treatment, prevention, and policy
|January 20, 2024
概括
大脑衍生神经营养因子 (BDNF) 水平在破裂海洛因使用者中较低,在戒断期间增加. 较低的BDNF与更高的物质使用相关,表明BDNF是成严重性的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 成 药物 药物 药物 药物
- 生物化学 生物化学
背景情况:
- 破解海洛因是一种高度成的阿片类衍生物,通过神经化学变化引起大脑功能障碍.
- 脑衍生神经营养因子 (BDNF) 与物质使用障碍神经病理学和戒断严重程度有关.
研究的目的:
- 在21天戒断期之前和之后,评估crack海洛因使用者的血清脑衍生神经营养因子 (BDNF) 水平.
主要方法:
- 一项涉及148名男性参与者的横截面研究 (74名克拉克海洛因使用者,74名对照).
- 血清BDNF水平测量使用酶相关的免疫吸收剂测定在住院治疗和21天后的撤回.
主要成果:
- 与出院和对照组相比,破裂海洛因使用者在入院时的BDNF水平明显较低 (p<0.05).
- 在毒海洛因使用者 (p=0.038) 中,从入院到出院的BDNF水平显著增加 (p=0.038).
- BDNF水平与每日物质剂量 (r=-0.420,p=0.03) 和使用时间 (r=-0.235,p=0.001) 相反相关.
结论:
- 在早期解毒期间BDNF的逐渐增加与物质使用强度相关.
- 血清BDNF水平的变化可能成为戒断症状强度和物质使用行为的潜在生物标志物.
更多相关视频
09:54Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
Published on: March 8, 2020
5.3K
09:29Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
2.2K
相关概念视频
Drug Dependence
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
