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在大鼠内分泌器官中的N-Nitrosomorpholine诱导的细胞转化

Emre Gezer¹, Cüneyt Özer², Turgay Şimşek³

¹Division of Endocrinology and Metabolism, Darica Farabi Training and Research Hospital, Kocaeli, Turkey. gezeremre@gmail.com.

European journal of medical research

|January 20, 2024

概括

暴露于N-Nitrosomorpholine (NMO) 导致大鼠内分泌腺体的瘤细胞变化,特别是胰腺,甲状腺,垂体和上腺. 这项研究强调了NMO作为细胞瘤的潜在环境风险因素.

科学领域:

内分泌学在内分泌学.
毒理学毒理学毒理学
病理学病理学病理学

背景情况:

N-Nitrosomorpholine (NMO) 是一个普遍存在的N-nitroso化合物.
以前的研究表明,NMO在老鼠管中诱导细胞转化.
NMO对内分泌器官的影响在很大程度上仍未被探索.

研究的目的:

研究N-Nitrosomorpholine (NMO) 诱导六个内分泌器官瘤细胞转换的潜力.
评估NMO暴露在甲状腺,上腺,垂体,胰腺,丸和大鼠骨中的病理影响.

主要方法:

使用了30只雄性大鼠,其中15只接受单次口服NMO (320 mg/kg) 剂量.
在52周后,内分泌器官 (垂体,甲状腺,胰腺,上腺,大腿骨,丸) 被切除用于组织学检查.
对照组和暴露于NMO的组进行了对比,对细胞细胞的发育进行了比较.

主要成果:

在对照组中没有观察到瘤细胞的发展.
在13只接受NMO治疗的老鼠中,有8只被检测到细胞.
受影响的器官包括上腺 (2只老鼠),甲状腺 (1只老鼠),垂体腺 (3只老鼠) 和胰腺 (2只老鼠).
丸和骨段没有显示任何异常.

结论:

显然,N-Nitrosomorpholine (NMO) 诱导胰腺,甲状腺,垂体和上腺的瘤细胞变化.
这项研究确定了内分泌腺体瘤细胞瘤的潜在环境风险因素.
由于对环境化学物质暴露的担忧,需要进一步研究NMO诱导的细胞瘤病理机制.

关键词:

内分泌干扰化学物质干扰内分泌的化学物质内分泌干扰物干扰内分泌干扰物内分泌腺新生体内分泌腺瘤.化物化合物化物化合物细胞瘤细胞是什么?

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