益生菌的肠道输送:材料,策略和应用
Chengcheng Li1, Zi-Xi Wang2, Huining Xiao3
1International Innovation Center for Forest Chemicals and Materials and Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing, 210037, China.
Advanced materials (Deerfield Beach, Fla.)
|January 21, 2024
概括
研究人员正在利用纳米技术和合成生物学改善益生菌向肠道的输送. 这提高了益生菌的生存和殖民,以更好地调节肠道微生物群和治疗应用.
科学领域:
- 微生物学 微生物学
- 纳米技术 纳米技术
- 合成生物学 合成生物学
背景情况:
- 益生菌调节肠道微生物群,但在分娩期间面临生存能力和殖民化的挑战.
- 简单的口服输送方法限制了益生菌的稳定性,可控性和临床用途的向性.
研究的目的:
- 审查用于肠道输送的益生菌类型.
- 探索当前的益生菌封装策略 (化学,物理,遗传).
- 讨论工程益生菌和未来的趋势.
主要方法:
- 各种益生菌封装技术的概述.
- 讨论用于单细胞益生菌封装的纳米涂层.
- 对益生菌作用机制的分析.
主要成果:
- 纳米技术改善了肠道中的益生菌生存和耐药性.
- 合成生物学使益生菌的高效设计和操纵成为可能.
- 工程益生菌显示出对先进的治疗应用有前途.
结论:
- 封装和工程是克服益生菌输送挑战的关键.
- 先进的益生菌特性可以带来更好的健康益处.
- 未来的研究趋势集中在开发复杂的工程益生菌上.
相关概念视频
01:18Drug Delivery: Enteral Route
456
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
456
01:26Enteral Nutrition I: Orogastric and Nasogastric Feeding
289
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
289
01:16Drug Delivery: Overview
294
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
294