缺少的基因组资源为下一代环境风险评估的下一代
Marc-Sven Roell1, Mark-Christoph Ott1, Magdalena M Mair2,3
1R&D Bayer AG, Crop Science Division, Monheim am Rhein 40789, Germany.
Environmental science & technology
|January 21, 2024
概括
基因组数据缺口阻碍了环境风险评估新方法方法 (NAM) 的开发. 需要有系统的努力来产生关键物种的基因组资源,使非动物测试成为可能.
科学领域:
- 生态毒理学 生态毒理学
- 基因组学就是基因组学.
- 环境风险评估环境风险评估
背景情况:
- 传统的生态毒理学风险评估严重依赖于体内试验,这是昂贵的,耗时的,并且在道德上令人担忧.
- 新方法方法 (NAMs) 提供了有前途的替代方案,但通常需要替代物种的高质量基因组数据,目前缺乏这种数据.
- 对监管代理物种缺乏全面的基因组信息,阻碍了NAM的发展和验证.
研究的目的:
- 为监管生态毒理学风险评估中使用的物种提供目前缺少的基因组资源的基因组学信息概述.
- 突出了协调社区努力产生这些基本基因组数据集的关键需求.
- 在系统毒理学框架内讨论标准化基因组景观的潜力,以便在系统毒理学框架内进行可靠的无动物生态毒理学评估.
主要方法:
- 遗传学分析,以识别和绘制监管代理物种基因组数据中的差距.
- 对生态毒理学模型的现有基因组资源进行文献审查和数据库评估.
- 为标准化基因组替代物种景观开发概念框架.
主要成果:
- 识别缺乏NAM开发所需的关键基因组信息的特定基因组分类和物种.
- 在关键代用物种中量化缺失基因组数据的程度.
- 一个明确的路线图,概述基因组资源生成的优先领域.
结论:
- 解决已识别的基因组数据缺口对于加速在环境风险评估中开发和实施NAM至关重要.
- 一个系统的,社区驱动的方法来产生基因组资源将促进向更道德和更有效的生态毒理学评估的过渡.
- 建立一个标准化的基因组替代物种景观对于推进系统生态毒理学和实现不依赖动物的风险评估至关重要.
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