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基于Co,Mo化电纳米纤维的敏感传感平台,用于同时电化学检测多巴胺和尿酸

Yukun Xing¹, Chengkai Lv¹, Yue Fu¹

¹Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, 710069, Xi'an, China.

|January 21, 2024

概括

一种使用和添加碳纳米纤维 (Co,Mo@CNFs) 的新型电化学生物传感器,可灵敏同时检测多巴胺 (DA) 和尿酸 (UA). 这一进步为临床诊断和生物分析提供了一种可靠的方法.

科学领域:

电化学电化学电化学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

多巴胺 (DA) 和尿酸 (UA) 的异常水平是与各种疾病相关的关键健康指标.
对DA和UA的敏感和同时检测方法对于准确的疾病诊断至关重要.
现有的方法面临诸如同时氧化过程中的重叠信号等挑战.

研究的目的:

开发一种高度灵敏和精确的电化学生物传感器,用于同时检测DA和UA.
为了提高电化学性能,合成和表征和配合的碳纳米纤维 (Co,Mo@CNFs).
评估生物传感器在生物样本中检测DA和UA的有效性.

主要方法:

通过电制合成Co,Mo@CNFs,然后进行碳化.
一个Co,Mo@CNFs修改的玻璃碳电极 (Co,Mo@CNFs/GCE) 的制造.
用于同时检测DA和UA的电化学表征和性能评估,包括抗干扰研究和在血清和尿液样本中的应用.

主要成果:

Co,Mo@CNFs/GCE表现出增强的电催化活性和快速的电子转移.
在同时检测DA和UA时,实现了显著的灵敏度和选择性,克服了峰值重叠问题.
达到了低检测极限:DA为2.35nmol L-1和UA为0.16μmol L-1.
该生物传感器在应用于稀释的血清和尿液样本时表现出高可靠性和精度.

结论:

开发的Co,Mo@CNFs/GCE电化学生物传感器提供了一个灵敏,准确和可靠的平台,用于同时检测DA和UA.
和的协同作用显著改善了电极的性能.
这种生物传感器具有临床诊断和生物分析应用的巨大潜力.

关键词:

多巴胺是一种多巴胺.电子制纳米纤维的纳米纤维.同时进行电化学检测检测.封装的过渡金属封装.尿酸是什么尿酸是什么

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