控制营养状况得分与缺血性中风患者与活跃癌症患者的结果之间的关联
Rei Sakurai1, Yasufumi Gon1, Yuki Shimada1
1Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
概括
营养状况影响癌症缺血性中风患者的生存率. 较差的营养与较差的结果相关,但经过调整后,这种关联在统计学上并非独立.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 营养状况对患有缺血性中风同时患有活跃癌症的患者的生存期的预后影响尚未明确.
- 了解这种关系对于优化患者护理和复杂的双诊断人群的结果至关重要.
研究的目的:
- 研究通过控制营养状况 (CONUT) 评分评估的营养状况与缺血性中风和活跃癌症患者的存活率之间的关联.
- 确定该患者队列中死亡率的独立预测因素.
主要方法:
- 对158名在2006年至2016年期间入院的患有癌症的缺血性中风患者进行了回顾性分析.
- 患者被分为四个营养状况组 (正常,轻度,中度,严重) 使用CONUT评分.
- 使用卡普兰-梅尔曲线和考克斯回归模型进行了生存分析,以评估死亡风险.
主要成果:
- 较低的营养状况,由较高的CONUT分数表明,与更差的生存结果显著相关 (日志等级测试,p < 0.001).
- 无变量分析显示,中度和严重营养不良的死亡风险增加.
- 然而,在调整了混因素后,营养状况并没有成为死亡率的独立预测因素. 过去的中风,远程转移和入院的D-二次数水平是独立的预后因素.
结论:
- 根据CONUT评分评估的营养状况,似乎是癌症活跃的缺血性中风患者的显著预后指标.
- 尽管观察到这种关联,但营养状况在多变量调整后并不能独立预测该研究群体的存活率.
- 需要进一步的研究来阐明营养的独立作用,并制定有针对性的干预措施.
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