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一种精简的受控扩张覆盖的形支架用于TIPS治疗PHT

Zhuxiang Xiong¹, Xiaoze Wang², Yuling Yan²

¹Department of Mechanics & Engineering, College of Architecture & Environment, Sichuan University, Chengdu 610065, China; Sichuan University Yibin Park/Yibin Institute of Industrial Technology, Yibin 644000, China.

Journal of biomechanics

|January 21, 2024

概括

一个新的精简的缩型支架用于跨内肝移植系统分流 (TIPS) 程序,可以提高降低带压梯度 (PCG) 的精度. 这种渐变的支架设计有助于比传统的直径相同的支架更有效地实现目标压力降低.

科学领域:

干预性放射学干预性放射学
医疗设备工程医疗设备工程
肝病学肝病学是一种肝病学.

背景情况:

跨内肝移植系统突变 (TIPS) 对于通过降低带压力梯度 (PCG) 来管理肝硬化并发症至关重要.
目前使用相同直径支架的TIPS程序在实现TIPS后的目标PCG方面缺乏准确性.
随着标准的支架放置,可能会发生显著的压力下降和循环流.

研究的目的:

为TIPS引入一种新的受控扩张,精简,覆盖的缩型支架.
在模拟环境中,与直径相同的支架相比,评估这种形支架的血液动力学效应.

主要方法:

基于患者CT血管造影数据,开发线状和相同直径支架的虚拟3D模型.
进行了数值模拟,以评估TIPS后的PCG和流动动态.
与24名患者的临床测量进行模拟的PCG和静脉动流的比较.

主要成果:

模拟显示,只有2名患者使用直径相同的支架实现了目标PCG.
使用6毫米和10毫米相同直径的支架导致PCG在大多数患者的安全范围之外,并观察到循环流.
在24名患者中,17名患者的精简型形支架在TIPS后的PCG中达到目标10-12 mmHg范围,没有循环流.

结论:

精简的形支架有效地解决了与直径相同的支架出现的突然压力变化的问题.
这种新的支架设计改善了门静脉附近的血液动力学.
精简的形支架显示出作为TIPS程序的优质替代品的潜力.

关键词:

血液动力学血液动力学波塔卡瓦尔压力梯度 (PCG) 是一个压力梯度.门性高血压 (PHT) 是指门性高血压.支架是一种支架.跨内肝移植系统的分流 (TIPS)

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