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相关概念视频

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

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Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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在性结肠炎中增加ACE2和TMPRSS2表达.

Yuichiro Hamamoto1, Michihiro Kawamura2, Hiroki Uchida2

  • 1Department of Diagnostic Pathology, Kinki Central Hospital, Itami, Hyogo, Japan; Department of Pathology, Osaka University Graduate School of Medicine, Suita, Japan.

Pathology, research and practice
|January 21, 2024
PubMed
概括

这项研究在性结肠炎 (UC) 患者中发现了ACE2和TMPRSS2的增加表达,这表明这些SARS-CoV-2入口分子可能在UC病变发生中发挥作用.

关键词:
在ACE2中,ACE2是ACE2.在 COVID-19 疫情中,炎症性肠病是一种炎症性肠病.这就是SARS-CoV-2病毒.这就是TMPRSS2的原因.性结肠炎是一种

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科学领域:

  • 胃肠病学 胃肠病学
  • 免疫学 免疫学 免疫学
  • 病毒学 病毒学

背景情况:

  • 性结肠炎 (UC) 是一种炎症性肠病,其病因不明.
  • ангиотензин转化酶2 (ACE2) 和跨膜血清蛋白酶2 (TMPRSS2) 是SARS-CoV-2的关键进入分子.
  • 以前的报道表明ACE2,TMPRSS2和UC之间存在潜在的关联,但缺乏共识.

研究的目的:

  • 研究患有性结肠炎的患者结肠直肠组织中ACE2和TMPRSS2的表达水平.
  • 为了确定UC中的ACE2和TMPRSS2表达是否受到COVID-19大流行影响.

主要方法:

  • 在2018年至2021年期间,从60名个人 (30名UC患者,30名对照) 收集了结肠直肠样本.
  • 使用免疫组织化学分析了ACE2和TMPRSS2表达的比例和强度.
  • 进行了统计分析,以比较UC患者和对照人群之间的表达水平.

主要成果:

  • 与对照组相比,UC患者的ACE2表达比例显著增加.
  • 在UC患者中发现了TMPRSS2表达强度的显著增加.
  • 在UC中ACE2和TMPRSS2的表达水平不受COVID-19大流行影响.

结论:

  • 在性结肠炎患者的结肠和直肠中,ACE2和TMPRSS2被上调.
  • 这些发现表明ACE2和TMPRSS2在性结肠炎的发病过程中可能发挥作用.
  • 需要进一步的研究来阐明具体的机制.