通过可解释的机器学习来定量识别电子废物污染物对人类氧化应激的影响
Luhan Yang1, Tao Zhang1, Yanxia Gao1
1School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
Journal of hazardous materials
|January 21, 2024
概括
电子废物 (电子废物) 污染物,包括重金属和PAHs,对人类的氧化应激有很大影响. 类似污染物之间的相互作用会放大这些有害影响,影响DNA和脂质过氧化.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 职业医学 职业医学是专业的.
背景情况:
- 全球电子废物 (电子废物) 的产生日益增加,对环境和健康构成风险.
- 电子废物拆除释放出与人类氧化压力相关的各种污染物.
研究的目的:
- 量化电子废物污染物的同时暴露对氧化应激标志物的影响.
- 确定导致氧化损伤的关键污染物及其相互作用.
主要方法:
- 研究了在中国电子垃圾场附近的129个人.
- 在尿液中测量重金属,PAHs,OPFRs,BP和PAE的度.
- 采用可解释的机器学习框架来评估同时暴露的影响.
主要成果:
- 电子废物污染物解释了23%的氧化DNA损伤和18%的脂质过氧化变异.
- 重金属是氧化应激的主要驱动因素,其次是PAH和PAE.
- 同源性污染物相互作用对氧化应激产生了强烈的协同/添加效应.
结论:
- 同时暴露于电子废物污染物对人类的氧化应激有很大影响.
- 了解污染物相互作用对于评估电子垃圾对健康的风险至关重要.
- 开发了一个智能分析系统,用于高效的电子废物污染物数据处理.
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