与阻塞性睡眠相关的呼吸障碍和心脏代谢风险因素 - 一个葡萄牙出生队列
Mariana Costa1, Liane Correia-Costa2, Ana Cristina Santos3
1Faculty of Medicine, Universidade do Porto, Porto, Portugal; Department of Pediatrics, Centro Hospitalar de Leiria, Portugal.
Respiratory medicine
|January 21, 2024
概括
与睡眠相关的呼吸障碍 (SRBD) 影响13.4%的儿童,在男孩中更常见,并且与高血压和较低的HDL胆固醇有关. 肥胖加剧了这些心血管风险在儿童SRBD.
科学领域:
- 儿科健康 儿科健康
- 睡眠医学 睡眠医学
- 心血管疾病的风险
背景情况:
- 儿童阻塞性睡眠相关呼吸障碍 (SRBD) 诊断不足,并与心脏代谢问题有关.
- 之前的研究使用了精选的样本;需要基于人口的数据.
- 了解儿童SRBD患病率和风险因素对于公共卫生至关重要.
研究的目的:
- 为了确定基于人口的7岁儿童队列中SRBD的流行率.
- 为了研究SRBD和心脏代谢风险因素之间的关联,考虑到性别差异.
- 确定SRBD与与肥胖有关的心血管风险之间的潜在联系.
主要方法:
- 基于人口的出生队列 (第21代) 被利用.
- 7岁儿童的父母填写了儿童睡眠问卷 (PSQ).
- 关于性别,人体测量,血压和代谢标记 (脂质,葡萄糖,胰岛素,HOMA-IR) 的数据使用统计测试和后勤回归来收集和分析.
主要成果:
- SRBD的患病率为13.4%,男孩 (15.7%) 比女孩 (10.9%) 和超重/肥胖儿童 (22.0%) 的患病率更高.
- 患有SRBD的儿童表现出较高的缩血压和较低的HDL胆固醇水平.
- 经过调整后的分析显示,与更高的BMI-z-score,静脉压,胰岛素和HOMA-IR相关,但这些因BMI而减弱,除了SRBD肥胖儿童的较低HDL胆固醇外.
结论:
- 在青春期前的儿童中,SRBD显示男性占主导地位.
- SRBD可能会导致心血管风险,特别是在肥胖儿童中.
- 早期识别和管理SRBD对于预防长期健康后果至关重要.
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