在食道癌中与癌症相关的纤维细胞
Karen J Dunbar1, Kwok K Wong2, Anil K Rustgi1
1Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Cellular and molecular gastroenterology and hepatology
|January 21, 2024
概括
与癌症相关的纤维细胞 (CAFs) 推动食道癌的进展和治疗耐药性. 了解CAF生物学对于开发食道状细胞癌和腺癌的新诊断和疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 纤维细胞研究 纤维细胞研究
背景情况:
- 癌症相关纤维细胞 (CAFs) 是固体瘤的关键参与者,促进癌细胞的增殖,迁移,入侵,免疫抑制和治疗耐药性.
- CAF通过分泌因子,细胞外基质重塑和代谢支持来调解这些效应.
- 在食道癌中,CAF与较差的存活率和对化疗和放射治疗的耐药性相关,强调需要确定CAF的脆弱性.
研究的目的:
- 概述当前对食道癌中CAFs的理解,包括食道状细胞癌和食道腺癌.
- 探索CAF的招募,CAF介导的瘤发生,转移性传播和食道癌中的治疗抵抗机制.
- 识别知识缺口,并提出未来的研究方向,用于食道癌中的CAF生物学.
主要方法:
- 在食道癌症中对CAF进行现有研究的文献综述和综合.
- 对食道状细胞癌和食道腺癌中CAF作用的分析.
- 在食道癌亚型和前瘤状况中对CAF知识的比较.
主要成果:
- CAFs对食道癌的进展和治疗耐药性有显著的贡献.
- 研究重点存在显著差异,在食道状细胞癌中对CAF的研究比在食道腺癌中更多.
- 在食道癌中,特别是腺癌和巴雷特食道中,CAF机制仍未完全评估.
结论:
- 对CAF生物学进行进一步的研究对于推进食道癌诊断和治疗方法至关重要.
- 解决食道腺癌CAF的知识差距可能产生显著的临床影响.
- 针对CAF的漏洞,为新的食道癌症治疗提供了一个有希望的途径.
更多相关视频
相关概念视频
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Esophageal Strictures-I: Introduction
102
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
102
Barrett Esophagus-I: Introduction
98
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
98
Introduction to Fibroblasts
3.1K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.1K
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Barrett Esophagus-II: Clinical Manifestations and Management
154
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
154


