外基因组重塑骨关节炎缺陷:再生医学新兴潜力-一篇评论
Jaishree Sankaranarayanan1,2,3, Seok Cheol Lee2,3, Hyung Keun Kim2,3
1Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun, Korea.
International journal of stem cells
|January 21, 2024
概括
外体通过增强再生来治疗骨关节炎 (OA) 和软骨缺陷有前途. 本综述探讨了外体治疗作为一种优越的替代方案,以目前的基于细胞的治疗在骨科.
科学领域:
- 整形医生 整形医生 整形医生
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
背景情况:
- 骨关节炎 (OA) 是一种退行性关节疾病,其特点是软骨磨损,导致疼痛和残疾.
- 由于软骨的无血管和动脉瘤性质,难以治疗状缺陷.
- 目前的治疗方法,如微骨折和基于细胞的治疗方法,有效性有限,通常是由于细胞活力不清楚.
研究的目的:
- 对外体的治疗潜力进行审查,用于冠状腺缺陷和骨关节炎.
- 以突出突破外体基疗法在骨科应用的科学突破.
- 讨论生物材料在增强外体细胞输送和疗效方面的作用.
主要方法:
- 在组织愈合和抗炎疗法中对外体应用的文献综述.
- 对外体组合 (蛋白质,DNA,RNA) 和准能力的分析.
- 探索基于生物材料的生物制造,包括水凝和脱细胞化细胞外基质.
主要成果:
- 外体细胞因其再生载荷和细胞向能力而为冠状体缺陷提供强大的治疗益处.
- 外体是基于细胞的疗法的一个有希望的替代品,有可能克服细胞活力的局限性.
- 生物材料,特别是特定于组织的脱细胞化细胞外基质,可能会提高外体细胞治疗的有效性.
结论:
- 基于外体的疗法在治疗骨关节炎和冠状腺缺陷的再生医学方面取得了重大进展.
- 预计未来对外体治疗的发展将极大地影响整形外科领域.
- 外体提供了一个可行的和潜在的优越替代目前基于细胞的治疗软骨修复.
更多相关视频
09:48Large-Scale Preparation of Synovial Fluid Mesenchymal Stem Cell-Derived Exosomes by 3D Bioreactor Culture
Published on: July 26, 2022
4.4K
11:22Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
17.5K
相关概念视频
Overview of Exosomes
2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
