在肥胖的成年人中,中间与早晨的时刻型具有较低的血管胰岛素敏感性
Steven K Malin1,2,3,4, Mary-Margaret E Remchak1, Emily M Heiston5
1Rutgers University, New Brunswick, New Jersey, USA.
Diabetes, obesity & metabolism
|January 21, 2024
概括
与早晨时代型个体相比,中间时代型个体表现出血管胰岛素敏感性降低. 内皮功能中的这种差异可能会影响心血管疾病的风险.
科学领域:
- 循环节生物学 日间生物
- 心血管生理学心血管生理学
- 代谢健康 代谢健康
背景情况:
- 时刻型,是昼夜节律的指标,影响内皮功能.
- 晨间时间型 (MORN) 通常与较低的心血管疾病风险有关.
- 时间型对血管胰岛素敏感性的影响仍然未被探索.
研究的目的:
- 为了研究中间 (INT) 和早晨 (MORN) 年代型之间血管胰岛素敏感性的差异.
- 测试INT个体的血管胰岛素敏感性低于MORN个体的假设.
主要方法:
- 肥胖的成年人被分类为MORN或INT使用早上晚上问卷 (MEQ).
- 血管胰岛素敏感性被评估使用高胰岛素-高血糖,测量流媒体扩张 (FMD) 和微血管血液体积.
- 评估了血管扩张和血管收缩的血标志物,有氧健身 (VO2max) 和身体组成.
主要成果:
- 虽然MORN个体的VO2max较高,但脂肪质量在两组之间相似.
- 在调整了VO2max后,胰岛素减少了口和微血管血液体积在INT与MORN相比,在对VO2max进行调整后.
- INT个体的禁食酸盐和氨酸水平较低,较高的MEQ得分与改善的口病和较低的后缺血性流速相关.
结论:
- 与在早上评估时的早晨时代型相比,中间时代型与血管胰岛素敏感性降低有关.
- 需要进一步研究以阐明心血管疾病风险降低策略的时型特异性内皮功能变异.
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