超分子宿主-客人相互作用触发了从金属-有机框架中提取染料,用于从血清中双模式ATP传感
Xue Yang1, Jing Xu1, Zirui Wang1
1College of Science, Northeastern University, Shenyang, 110819, China.
Analytica chimica acta
|January 21, 2024
概括
一种新型的双模式生物传感器使用化物伊米达酸框架-90 (ZIF-90) 和罗达胺B检测腺三酸盐 (ATP). 这种高度敏感和选择性的系统显示出临床诊断的巨大潜力.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 腺三酸盐 (ATP) 对生命至关重要,其异常水平表明疾病.
- 精确的ATP检测对于诊断各种疾病至关重要.
研究的目的:
- 开发一种敏感和选择性的双模式传感系统,用于检测腺三酸盐 (ATP).
- 为了利用新型生物传感方法,使用化物伊米达酸框架-90 (ZIF-90) 和罗达胺B (RhB).
主要方法:
- 设计了一种采用微分脉冲电量计 (DPV) 和光 (FL) 技术的双模式传感系统.
- 该系统利用ZIF-90中的ATP和Zn (II) 节点之间的相互作用,导致RhB释放.
- β-环极素 (β-CD) 促进了无酶DPV和FL检测策略.
主要成果:
- 该DPV模式实现了10.0-1.0 × 108 pM的线性检测范围,检测极限 (LOD) 为0.13 pM.
- FL模式显示线性范围为10.0-1.0 × 10 pM和LOD为0.29 pM.
- 生物传感器表现出很好的长期稳定性,并在人体血清样本中成功验证.
结论:
- 开发的双模式传感平台提供敏感,选择性和无酶的ATP检测.
- 这种创新的生物传感器对体外诊断和临床应用具有重大前景.
- 该平台为医疗保健中先进的高性能生物传感器铺平了道路.
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