[全球结直肠癌患病率,预防和控制的现状]
1Henan Office for Cancer Control and Research, Henan Engineering Research Center of Cancer Prevention and Control, Henan International Joint Laboratory of Cancer Prevention, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China.
Zhonghua zhong liu za zhi [Chinese journal of oncology]
|January 21, 2024
概括
结肠直肠癌是全球主要的健康问题,排名第四的最常诊断的癌症. 了解它的流行病学和风险因素对于有效预防和减少全球和中国的疾病负担至关重要.
科学领域:
- 癌症的流行病学癌症的流行病学.
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 是一个重大的全球健康挑战.
- 2020年,CRC是全球第四常见的癌症诊断和癌症死亡的第三大原因.
- 在CRC发病率和死亡率方面存在显著的区域差异.
研究的目的:
- 为全球和中国提供结直肠癌流行病学概述.
- 讨论结直肠癌的预防策略,以减少疾病负担.
- 分析与结直肠癌相关的趋势和风险因素.
主要方法:
- 使用了GLOBOCAN 2020数据库,中国癌症登记处年度报告和CONCORD-3数据.
- 雇佣了微软Excel 2016和R 4.2.1用于数据管理.
- 使用ggplot2包进行结果解释生成的可视化.
主要成果:
- 在2020年,在全球范围内记录了1,931,590例新的CRC病例和935,173例死亡.
- 中国的年龄标准化发病率和死亡率分别为每10万人口中的17.3和7.8.
- 观察到的性别差异:女性的趋势下降,男性的趋势增加;确定了包括年龄,遗传,饮食和生活方式在内的关键风险因素.
结论:
- 结肠直肠癌在全球和中国的疾病负担很大.
- CRC的发生是多因素的,受生理,遗传,行为和生活方式因素的影响.
- 针对性的预防策略,重点是减少暴露于已确定的风险因素,并整合三级预防,对于有效的CRC控制至关重要.
相关概念视频
01:30Preventive Healthcare Services
1.0K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.0K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
01:26Levels of Health Promotion and Illness Prevention
12.6K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
12.6K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.9K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K