与IgG4相关的脏疾病:临床病理学特征,差异诊断和模仿
Sarwat I Gilani1, Alessia Buglioni2, Lynn D Cornell2
1Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, TX, USA.
Seminars in diagnostic pathology
|January 21, 2024
概括
与IgG4相关的脏疾病 (IgG4-RKD) 涉及与IgG4相关的疾病 (IgG4-RD) 相关的各种脏疾病. 这篇评论详细介绍了其多样化的表现,诊断标记和模仿,如ANCA相关疾病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 与IgG4相关的脏疾病 (IgG4-RKD) 是IgG4相关疾病 (IgG4-RD) 中脏表现的不断变化的谱.
- 最初被确定为IgG4相关的管介质性炎 (IgG4-TIN) 和IgG4相关的膜状质炎 (IgG4-MGN),现在包括多种介质,质和血管病理.
- 虽然IgG4-RKD通常是全身性,但在约20%的病例中,IgG4-RKD可以表现为限性疾病.
研究的目的:
- 为提供IgG4相关病 (IgG4-RKD) 的全面概述.
- 讨论IgG4-RKD的各种临床表现,诊断特征和差异诊断.
- 为了突出IgG4相关的管介质炎的模仿,特别是ANCA相关的疾病.
主要方法:
- 关于IgG4相关病 (IgG4-RKD) 和相关疾病的文献综述.
- 对IgG4-RKD的临床表现,病理模式和血清学发现的分析.
- 将IgG4-RKD与其他间歇性炎和球细胞疾病进行比较.
主要成果:
- IgG4-RKD可变地表现为急性/慢性损伤,蛋白尿,性综合征,质或阻塞.
- 与一般IgG4-RKD相比,IgG4-RKD患者经常表现出血清IgG4/IgG的升高和低补充血.
- 差异诊断包括其他自身免疫和富含血细胞的间歇性神经,炎症性质量病变以及与ANCA相关的疾病.
结论:
- IgG4-RKD是一种复杂的病,具有多种表现和诊断考虑.
- 识别IgG4-RKD的广泛范围对于准确的诊断和管理至关重要.
- 区分IgG4-RKD与模仿者,如ANCA相关疾病,对于适当的治疗策略至关重要.
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