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在患有牙牙周炎的患者中,COVID-19的严重程度:一项病例控制研究
Nadya Marouf1, Raidan Ba-Hattab2, Fatima Al-Sheeb1
1Division of Endodontics, Department of Dentistry, Oral Health Institute, Hamad Medical Corporation, Doha, Qatar; College of Dental Medicine, QU Health, Qatar University, Doha, Qatar; Hamad Dental Center, Hamad Medical Corporation, Doha, Qatar.
International dental journal
|January 21, 2024
概括
牙周上角性牙周炎 (AP) 的存在与患有严重COVID-19并发症的风险更高有关. 患有AP的患者表现出白细胞和HbA1c水平的增加,这表明潜在的炎症联系.
科学领域:
- 口腔健康和传染病研究.
- 牙感染的系统性影响.
背景情况:
- 阿皮性牙周炎 (AP) 与严重的COVID-19共享炎症生物标志物.
- 现有研究表明,系统性炎症和COVID-19严重程度之间存在联系.
研究的目的:
- 为了调查牙周顶部炎和发生严重COVID-19并发症的风险之间的关联.
- 测试AP增加COVID-19并发症风险的假设.
主要方法:
- 卡塔尔949名COVID-19患者的病例控制研究 (2020年3月至2021年2月).
- 病例 (n=63) 有COVID-19并发症;对照组 (n=886) 没有并发症.
- 在感染之前对AP的放射性评估;为混因素调整后的后勤回归分析.
主要成果:
- 牙周炎与COVID-19并发症的增加显著相关 (aOR=2.72,P=.008).
- 与没有AP的患者相比,患有AP的COVID-19患者的白细胞计数和HbA1c水平升高.
结论:
- 这些发现表明,顶性牙周炎可能是严重的COVID-19结果的独立风险因素.
- 需要进一步的研究来阐明将AP与COVID-19严重程度联系在一起的机制.
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