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Updated: Jul 5, 2025

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针对骨的工程小细胞外囊携带抗miR-6359-CGGGAGC,防止酸诱导的骨损失

Xudong Xie1,2, Peng Cheng1,2, Liangcong Hu1,2

  • 1Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Signal transduction and targeted therapy
|January 21, 2024
PubMed
概括

瓦尔酸 (VPA) 通过通过miR-6359增加骨质细胞活性,导致骨质损失. 携带抗miR-6359的工程纳米粒子显示了对VPA诱导的骨损失的治疗潜力.

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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
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