肠道和膀发酵综合征:一个叙述性回顾
Kenichi Tamama1,2,3, Katherine M Kruckenberg4,5, Andrea F DiMartini5
1Clinical Laboratories, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. tamamakj@upmc.edu.
BMC medicine
|January 21, 2024
概括
膀发酵综合征 (BFS) 导致酵母在膀中产生乙醇,导致禁欲监测失败. 与肠道发酵综合征 (GFS) 不同,由于乙醇吸收低,BFS缺乏中毒症状.
科学领域:
- 医学真菌学 医学真菌学
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 膀发酵综合征 (BFS) 或尿道自动酒综合征是一种罕见的病症,在膀内酵母产生乙醇.
- BFS与控制不良的糖尿病和由Candida glabrata发酵有关,这是一个Crabtree阳性酵母.
- 与肠发酵综合征 (GFS) 不同,BFS的特点是由于膀上皮的低乙醇透性,没有酒精中毒.
研究的目的:
- 根据临床和实验室发现,区分BFS和GFS.
- 突出诊断挑战和潜在的法律影响的低认可的发酵综合征.
- 强调准确诊断对于适当的治疗和患者管理的重要性.
主要方法:
- 案例报告分析BFS和与GFS进行比较.
- 对诊断标准的审查,包括尿液分析 (葡萄糖,乙醇,代谢物,酵母存在) 和碳水化合物挑战测试.
- 讨论涉及抗真菌疗法和潜在疾病管理的治疗策略.
主要成果:
- 怀疑BFS是阳性尿液葡萄糖和乙醇,阴性乙醇代谢物和尿液分析中的酵母.
- 诊断GFS需要通过碳水化合物挑战测试证明内源性乙醇生产.
- 无论是BFS还是GFS都可能导致禁欲监测失败,GFS患者可能呈阳性血液酒精测试结果.
结论:
- 不充分承认BFS和GFS可能会对患者造成伤害和不利的法律后果,例如酒后驾驶指控.
- 有效的治疗包括根除发酵微生物并解决根本原因 (BFS的糖尿病,GFS的肠道失调).
- 区分BFS和GFS对于准确的诊断,治疗和预防与酒精有关的健康问题至关重要.
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