多发性硬化症患者的COVID-19结果:2020年至2022年的变化理解
Lina Jeantin1, Edouard Januel2, Pierre Labauge3
1Sorbonne University, Paris Brain Institute-ICM, Assistance Publique-Hôpitaux de Paris (AP-HP), Inserm, CNRS, Hôpital de la Pitié Salpêtrière, CIC Neurosciences, FCRIN4MS, Paris, France.
Multiple sclerosis (Houndmills, Basingstoke, England)
|January 22, 2024
概括
多发性硬化症 (pwMS) 患者的COVID-19严重程度随着时间的推移而下降,但抗CD20疗法和神经障碍仍然是关键风险因素. 接种疫苗显著减少了pwMS的严重结果.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 以前对多发性硬化症 (pwMS) 患者的COVID-19研究主要涵盖了早期的流行病浪潮.
- 扩展到广泛疫苗接种期间的pwMS中COVID-19结果的数据有限.
研究的目的:
- 分析从全球疫苗接种覆盖范围开始的pwMS中的COVID-19严重程度和风险因素.
- 评估疫苗接种和特定治疗对pwMS中COVID-19结果的影响.
主要方法:
- 使用COVISEP注册表进行的回顾性多中心观察研究.
- 在2020年1月至2022年7月期间,将已确认或高度怀疑的COVID-19病例纳入pwMS.
- 严重的COVID-19的定义是住院或更严重的严重性.
主要成果:
- 在pwMS中,严重的COVID-19发病率显著下降,从Omicron前的14.6%降至Omicron波期间的5.7%.
- 严重的COVID-19的独立风险因素包括年龄较大,男性性别,肥胖,心脏伴随性疾病,更高的扩展残疾状态量表 (EDSS) 评分和抗CD20疗法.
- 接种疫苗与pwMS中COVID-19严重程度的降低有关,无论是使用或不使用抗CD20疗法.
结论:
- 抗CD20疗法和神经障碍 (EDSS) 是一致的,对于pWMS中COVID-19严重性的显著风险因素.
- 这些因素会影响COVID-19的严重程度,不管是疫情浪潮,时间段或疫苗接种情况.
- 疫苗接种在缓解pwMS中严重的COVID-19结果方面发挥着至关重要的作用.
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