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相关实验视频

Updated: Jul 5, 2025

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
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一个模块化的微流体有机体平台使用乐高式块.

Daniel J Carvalho1, Anna M Kip2, Andreas Tegel3

  • 1Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

Advanced healthcare materials
|January 22, 2024
PubMed
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此摘要是机器生成的。

一个新的模块化流体电路板 (FCB) 系统集成有机体与芯片器官 (OoC) 技术. 这种灵活的平台简化了3D细胞模型的动态培养,克服了目前的局限性.

科学领域:

  • 生物技术是生物技术.
  • 微流体学 微流体学
  • 组织工程是组织工程.

背景情况:

  • 目前的3D体外模型,包括有机体,在标准的器官芯片 (OoC) 系统中面临局限性.
  • 将有机体集成到OOC中具有技术挑战,导致复杂和低效的细胞培养协议.
  • 需要可适应的微流体平台来整合复杂的3D体外模型.

研究的目的:

  • 开发一个灵活和用户友好的微流体平台,用于有机体的动态培养.
  • 克服当前将有机物集成到OOC系统中的方法的局限性.
  • 为了促进有机体技术与先进的微流体平台的结合.

主要方法:

  • 开发一个模块化,无管流体电路板 (FCB) 系统.
  • 通过在聚碳酸板中制道和热粘合来制造FCB.
  • 集成的乐高类流体连接器和锁和玩的,用于细胞培养.
  • 使用开发的平台,使用胚胎干细胞衍生的甲状腺毛囊的动态培养.

主要成果:

  • 开发的FCB系统允许轻松快速地 (卸载) 有机物.
  • 甲状腺器官在芯片上成功培养了长达10天的时间,没有结构或功能损失.
关键词:
乐高乐高® 乐高® 乐高® 乐高®微流体学 在微流体学方面这是一个模块化的模块化系统.有机生物有机物器官在芯片上的器官甲状腺是什么?甲状腺是什么?

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  • 一个多重输液实验证明了该系统对并行实验的能力.

    • 结论:

    • 模块化FCB平台为将有机体与微流体系统集成提供了灵活和高效的解决方案.
    • 这项技术简化了用于3D体外模型的动态培养协议.
    • 该系统通过使协同组合成为可能,有望推动有机物和OOC研究.