不精选的来自捐赠者的造血干细胞促进了化学抗原受体T细胞相关的血液毒性
Eugenio Galli1, Maria Assunta Limongiello1, Elisabetta Metafuni1
1Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
American journal of hematology
|January 22, 2024
概括
化学抗原受体-T治疗后的血液毒性通过干细胞增强得到解决. 这种干预导致由于捐赠淋巴细胞导致受控的移植对宿主疾病爆发.
科学领域:
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
- 移植免疫学 移植免疫学
背景情况:
- 化学抗原受体-T (CAR-T) 疗法是一种用于血液恶性瘤的新型免疫疗法.
- 之前的异性干细胞移植 (allo-SCT) 对随后的CAR-T疗法提出了独特的挑战,包括潜在的血液毒性.
- 在接受CAR-T治疗的有alo-SCT病史的患者中,管理并发症需要仔细考虑.
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