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在胰腺β细胞系中稀释的花基纳米配方的抗氧化和抗糖尿病特性
Elisabetta Schiano1,2, Ettore Novellino3, Marta María Gámez Fernández4
1Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 59, 80131 Naples, Italy.
Antioxidants (Basel, Switzerland)
|January 22, 2024
概括
稀释 nektarin 提取物 (TNE) 的纳米配方增强胰腺细胞中的抗氧化剂和胰岛素分泌. 这种方法提高了生物活性化合物的生物可用性,为糖尿病管理提供了一个有希望的策略.
科学领域:
- 生物化学 生物化学
- 营养保健品 营养保健品
- 细胞生物学 细胞生物学
背景情况:
- 胰腺β细胞对于葡萄糖平衡至关重要,但易受氧化应激的影响.
- 稀释 nektarines (TNs) 含有多和酸 (ABA),具有潜在的抗糖尿病作用.
- 生物可用性和稳定性问题限制了TN生物活性化合物的体内疗效.
研究的目的:
- 开发酸 (ABA) 和稀释花提取物 (TNE) 的纳米配方 (NF).
- 为了比较NFs的胰岛素和抗氧化潜力与胰腺细胞中的自由形式.
- 评估不同葡萄糖和铁度对细胞反应的影响.
主要方法:
- 在同等ABA度下开发含有纯ABA或TNE的纳米配方 (NFs).
- 在不同的葡萄糖 (5.5毫米,20毫米) 和铁 (100微米) 条件下用NF和自由形式治疗MIN-6胰腺细胞.
- 治疗细胞中抗氧化活性和胰岛素分泌 (胰岛素AUC) 的评估.
主要成果:
- 与自由TNE相比,NF-TNE显示出显著增强的抗氧化活性.
- 基于ABA的组没有显著的抗氧化活性.
- 所有治疗都增加了暴露于高葡萄糖和铁的细胞中的胰岛素AUC,NF-TNE显示出最显著的效果.
结论:
- 稀释 nektarin 提取物 (TNE) 提供超出其酸 (ABA) 含量的协同效益.
- 纳米配方显著增强了TNE的抗氧化和胰岛素otropic潜力.
- 这项研究强调了纳米配方在改善糖尿病管理中的植物活性化合物的疗效方面的优势.
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