在ADHD治疗后皮质醇和氧化/酸性压力指标的变化
Laura Garre-Morata1, Tomás de Haro1,2, Raquel González Villén3
1UGC of Laboratorios Clínicos, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.
Antioxidants (Basel, Switzerland)
|January 22, 2024
概括
甲基胺治疗改善了ADHD儿童的氧化应激标志物和抗氧化活性. 这项研究还揭示了皮质醇唤醒反应的增加,表明增强了下丘脑-垂体-上腺轴的反应性.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 儿科 儿科 儿科
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种常见的童年障碍,其起源不明.
- 氧化应激和下丘脑-垂体-上腺 (HPA) 轴与ADHD病理生理学有关.
- 甲基胺对与ADHD相关的生物标志物的影响尚未完全理解.
研究的目的:
- 研究甲基胺治疗对ADHD患者氧化/化压力标志物和皮质醇唤醒反应 (CAR) 的影响.
- 评估甲基胺治疗后内源性抗氧化活性和HPA轴反应性的变化.
主要方法:
- 研究了一组59名被诊断患有多动症的儿童 (DSM-5标准).
- 血液和唾液样本在甲基化物治疗3个月之前和之后收集.
- 测量了氧化应激标志物 (AOPP,LPO,NOx),抗氧化酶活性 (GRd,CAT) 和CAR.
主要成果:
- 甲基酸盐治疗导致高级氧化蛋白产物 (AOPP),脂质过氧化 (LPO) 和酸盐/酸盐 (NOx) 水平显著降低.
- 谷氨还原酶 (GRd) 和酶 (CAT) 的酶活性显著增加.
- 曲线 (AUC) 下的皮质醇唤醒反应 (CAR) 区域增加,表明HPA轴反应性增加.
结论:
- 甲基胺治疗积极调节ADHD患者的氧化还原特征.
- 这些发现为内源性抗氧化剂系统在ADHD病理生理学中的参与提供了第一个证据.
- 用甲基酸盐治疗增强了ADHD儿童的HPA轴反应性.
关键词:
注意缺陷多动障碍 (ADHD) 是一种注意缺陷多动障碍.皮质醇是一种皮质醇.皮质醇唤醒反应 (CAR)这是一种炎症炎症炎症炎症.克洛托托克洛托克 (克洛托托克) 是一个甲基化甲基化氧化应激是一种氧化应激.更多相关视频
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