基托桑基基基的抗衰老特性 富含蓝果提取物
Elżbieta Studzińska-Sroka1, Magdalena Paczkowska-Walendowska1, Cansu Erdem2
1Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3 Str, 60-806 Poznań, Poland.
Antioxidants (Basel, Switzerland)
|January 22, 2024
概括
富含多的蓝果实提取物显示为局部抗衰老治疗的前景. 优化的水凝有效地提供这些化合物,这表明一种天然方法来对抗皮肤衰老.
科学领域:
- 化品科学 化品科学
- 自然产品化学 自然产品化学
- 皮肤病学 皮肤病学
背景情况:
- 由活性氧物种 (ROS) 驱动的光衰老加速了皮肤的衰老.
- 聚醇具有抗氧化特性,可以减轻自由基的破坏并延迟皮肤衰老.
研究的目的:
- 为了制备一个生物活性提取物从黑 (Vaccinium myrtillus或Vaccinium corymbosum) 果实.
- 为局部抗衰老应用而配制含有蓝提取物的基托桑基水凝.
主要方法:
- 植物化学分析 (总聚,黄,) 和生物活性评估 (抗氧化剂,抗氨酸酶,抗氨酸酶) 的八种不同的蓝提取物.
- 在HaCaT角质细胞上进行细胞毒性测试.
- 使用实验设计方法制备奇托桑水凝,优化提取物和奇托桑度.
- 评估水凝粘度,活性化合物释放和酶抑制活性.
主要成果:
- V. myrtillus的酸盐和水提取物显示出显著的植物化学和生物活性.
- 基于基托桑的水凝显示出增强的抗氨酶和抗铁酶活性,这是由于蓝提取物和基托桑的联合存在.
- 更高的奇托桑度增加了水凝的粘度,并减缓了活性化合物的释放.
- 使用1%的蓝提取物和2.5%的中等分子量 (MMW) 奇托桑,可以达到最佳的水凝特性.
结论:
- 果提取物由于其多含量,具有显著的抗衰老潜力.
- 基于基托桑的水凝是用于局部抗衰老配方中的蓝提取物的有效输送系统.
- 开发的水凝为缓解光衰老效应提供了一个有希望的自然策略.
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