亚纳斯特罗通过改善反应性氧物种介导的炎症反应来保护人类的冠状病毒感染
Eun-Bin Kwon1, Buyun Kim1, Young Soo Kim1
1Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM), Dong-gu, Daegu 41062, Republic of Korea.
Antioxidants (Basel, Switzerland)
|January 22, 2024
概括
亚纳斯特罗 (AZ) 对人类冠状病毒HCoV-OC43和HCoV-229E.表现出抗病毒作用. 这种药物减少了HCoV-OC43感染细胞中的炎症,NLRP3炎症酶激活和热.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 常见的人类冠状病毒 (HCoV) 引起轻度呼吸道疾病.
- HCoV-OC43是研究SARS-CoV-2的相关模型.
- 安醇 (AZ) 是FDA/EMA批准的药物,具有潜在的抗病毒应用.
研究的目的:
- 在体外测定阿纳斯特罗 (AZ) 对HCoV-OC43和HCoV-229E的抗病毒作用.
- 研究AZ对HCoV-OC43的疗效背后的机制,重点关注炎症和细胞死亡途径.
主要方法:
- 在体外抗病毒试验中,使用MRC-5细胞感染HCoV-OC43和HCoV-229E.
- 测量炎症性细胞因子分泌 (TNF-α,IL-6,IL-1β).
- 评估NF-κB转位,细胞内和ROS水平,NLRP3炎症组分,切割IL-1β,细胞活力和切割气皮素D (GSDMD).
主要成果:
- 亚纳斯特罗 (AZ) 对HCoV-OC43和HCoV-229E都表现出抗病毒活性.
- AZ显著降低了炎症性细胞因子分泌,并抑制了HCoV-OC43感染细胞中的NF-κB转位.
- AZ减轻了病毒诱导的细胞内和ROS,抑制了NLRP3炎症酶激活,并减少了烧亡标志物.
结论:
- 阿纳斯特 (AZ) 对常见的人类冠状病毒具有显著的抗病毒特性.
- AZ有效地抑制炎症反应和细胞损伤途径,包括NLRP3炎症酶激活和热死.
- 作为治疗新冠肺炎感染的治疗剂,AZ显示出前景.
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