探索基于尼克洛萨米德的胆固醇增强剂在抗胆固醇抗性格拉姆阴性细菌中的结构-活性关系

Liam Berry1, Quinn Neale1, Rajat Arora1

  • 1Department of Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

PubMed
概括

科学家们探索了尼克洛萨米德类似物,以提高胆固醇对抗耐药性氏阴性细菌的有效性. 一种新的化合物表现出类似的胆固醇增强活性,具有较低的毒性,为抗生素开发提供了一个有前途的途径.

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