通过皮肤输送的配方:从水凝到乳液
Patrícia Matos1,2,3, Maria Teresa Batista3, Francisco Veiga1,2
1Univ. Coimbra, Faculty of Pharmacy, 3000-548 Coimbra, Portugal.
Gels (Basel, Switzerland)
|January 22, 2024
概括
这项研究探讨了针对皮肤疾病的局部Acanthus mollis叶片配方. 一个关键的化合物DIBOA在水凝中释放得最优,这表明它有可能用于治疗炎症和黑色素瘤.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 皮肤病学 皮肤病学
- 自然产品化学 自然产品化学
背景情况:
- 阿坎图斯 (Acanthus mollis L.) 叶是一种传统的药用植物.
- 局部药物递送系统需要优化,以获得有效的生物可用性.
- 了解活性化合物的释放动力学对于治疗疗效至关重要.
研究的目的:
- 首次研究Acanthus mollis L.叶的局部配方.
- 从这些配方中优化活性化合物的释放和局部生物可用性.
- 评估DIBOA作为皮肤应用的关键生物活性剂的潜力.
主要方法:
- 开发了油在水中的奶油和两个水凝配方 (Carbopol 940,Pluronic F-127).
- 使用弗朗茨扩散细胞进行体外释放研究.
- 使用光二极管阵列检测 (HPLC-PDA) 的高性能液体染色学量化活性化合物,特别是DIBOA.
主要成果:
- 在Carbopol和Pluronic F-127水凝配方中,DIBOA显示了韦布尔释放动力学.
- 该研究确定了DIBOA作为优化局部分布的潜在活性剂.
- 配方在针对炎症和铁酶抑制的局部应用方面表现有前途.
结论:
- 叶子提取物Acanthus mollis L.可以配制用于局部输送.
- DIBOA的释放动力学支持其在优化的局部配方中使用.
- 这些发现表明,对于诸如黑色素瘤和炎症性疾病等皮肤疾病的潜在治疗应用.
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