基于水凝的椎间盘再生策略:进展,挑战和临床前景
Shivam U Desai1, Sai Sadhananth Srinivasan2, Sangamesh Gurappa Kumbar2
1Department of Orthopedic Surgery, Central Michigan University, College of Medicine, Saginaw, MI 48602, USA.
Gels (Basel, Switzerland)
|January 22, 2024
概括
水凝对治疗椎间盘退化 (IVD) 有希望,提供一种超出症状控制的疾病修饰方法. 本综述探讨了用于IVD修复和再生的水凝应用.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 整形外科 整形外科 整形外科
背景情况:
- 椎间盘 (IVD) 退化导致广泛的腰部疼痛和残疾.
- 衰老导致细胞核脱水和纤维环裂,导致或崩.
- 目前的治疗方法专注于症状管理,缺乏疾病修饰的选择.
研究的目的:
- 审查用于脊椎间盘 (IVD) 修复的水凝技术的最新进展.
- 突出水凝作为IVD退化的疾病修饰治疗的潜力.
主要方法:
- 关于用于脊椎间盘 (IVD) 修复的水凝应用的当前文献的综述.
- 在体外和体内研究的分析,调查水凝的疗效.
- 与IVD再生相关的水凝特性概述.
主要成果:
- 水凝具有生物相容性和可调节的机械性能.
- 水凝可以吸收和保留水,模仿原生细胞核.
- 许多水凝已被探索用于IVD修复,其中一些接近临床应用.
结论:
- 水凝为有效的椎间盘退化 (IVD) 治疗提供了一个有希望的途径.
- 需要进一步研究和临床翻译水凝技术.
- 水凝对目前用于IVD疾病的以症状为中心的治疗方法来说是一个显著的进步.
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