高蛋白饮食通过缺席的黑色素瘤2炎症体促进心房节律失调
Jia Song1, Jiao Wu2, Dexter J Robichaux3
1Department of Medicine, Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX 77030, USA.
Cells
|January 22, 2024
概括
高蛋白饮食通过激活AIM2炎症酶来增加心房动的风险,导致心脏细胞中异常释放. 针对这种途径可能会提供新的心房的治疗方法.
科学领域:
- 心脏病学 心脏病学
- 分子生物学分子生物学
- 饮食科学 饮食科学
背景情况:
- 高蛋白饮食 (HPD) 与体重管理和代谢改善有关.
- HPD对心脏节律失常,特别是心房 (AF) 的影响尚不清楚.
- 炎症酶激活,特别是涉及缺席黑色素瘤2 (AIM2),与AF有关,但其在HPD诱导的AF中的作用尚未被探索.
研究的目的:
- 为了研究HPD对AF易感性的影响.
- 确定AIM2炎症酶信号在HPD诱导的AF中的作用.
- 阐明连接HPD,AIM2激活和AF的机制.
主要方法:
- 野生型和Aim2缺乏的小鼠在4周内被食正常或HPD.
- 评估了炎症酶活性,细胞质DNA水平,线粒体反应性氧物种 (ROS) 和质网膜 (SR) Ca2+释放.
- 在不同小鼠组中评估了AF易感性.
主要成果:
- 在野生型小鼠中,HPD显著增加了对AF的敏感性.
- 在HPD养野生型小鼠的心房中,炎症酶活性和细胞质双链DNA水平升高.
- 在Aim2缺乏的小鼠中,AIM2的遗传抑制减弱了HPD诱导的AF,减少了细胞质dDNA,线粒体ROS和正常化的SR Ca2+释放.
结论:
- HPD通过激活AIM2炎症酶通路来促进AF的发展.
- 由HPD激活AIM2与线粒体氧化应激和前节律SR Ca2+释放有关.
- 向AIM2炎症酶可能是针对特定患者群体的AF的新治疗策略.
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