开发基于天生的免疫细胞的免疫疗法,用于成人T细胞白血病-淋巴瘤
Maho Nakashima1, Yoshimasa Tanaka2, Haruki Okamura3
1Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.
Cells
|January 22, 2024
概括
使用新型双酸盐原药 (PTA) 和细胞因子扩大的玛三角型T细胞和自然杀手细胞的采用转移显示出治疗成人T细胞白血病-淋巴瘤 (ATL) 的前景. 这种细胞疗法有效地向HTLV-1感染的细胞,提供了潜在的新治疗选择.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
背景情况:
- 玛三角 (γδ) T细胞和自然杀手 (NK) 细胞是强大的细胞毒性淋巴细胞,对瘤和感染细胞有效.
- 成人T细胞白血病-淋巴瘤 (ATL),由HTLV-1引起,目前的疗法治疗选择有限.
- γδ T 细胞和 NK 细胞表达 CD16,使抗体依赖细胞细胞毒性.
研究的目的:
- 评估ex vivo扩展的γδ T细胞和NK细胞作为潜在的基于细胞的ATL治疗疗法的疗效.
- 用一种新型含双酸原药 (PTA) 和介质蛋白 (IL-2/IL-18) 来研究来自ATL患者的γδ T细胞和NK细胞的扩张效率.
主要方法:
- 来自55名ATL患者的外周血液单核细胞 (PBMC) 通过PTA和IL-2/IL-18被刺激以扩大γδ T细胞和NK细胞.
- NK细胞也通过培养CD3+ T细胞贫乏的PBMCs与IL-2/IL-18进行扩大.
- 扩展细胞对ATL细胞系的细胞毒性在体外评估.
- 研究了抗CCR4抗体对细胞中介细胞毒性的影响.
主要成果:
- γδ T 细胞的平均扩张率为 1998 倍,NK 细胞的扩张率为 12 倍,这表明有效的体外扩张.
- 扩张效率没有受到患者年龄或HTLV-1感染状态的显著影响.
- 反CCR4抗体增强了gδT细胞和NK细胞对TLV-1感染的CCR4+T细胞的细胞毒性活动,以剂量依赖的方式.
结论:
- 使用PTA/IL-2/IL-18进行γδ T细胞和NK细胞的活体扩张对于ATL患者是可行的和有效的.
- 这些扩大细胞的采用转移代表了ATL有前途的替代治疗策略.
- 用抗CCR4抗体增强细胞毒性表明一种潜在的组合治疗方法.
相关概念视频
Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
Cells of the Adaptive Immune Response
989
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
989
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Special Features of Adaptive Immunity
822
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
822
Cell-mediated Immune Responses
68.3K
Overview
68.3K
T Cell Activation and Clonal Selection
739
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
739


