尿素/肌氨酸比率与COVID-19小儿肌肉炎患者肌酸激酶正常化的相关性:评估预后和预测值
Francesco Pizzo1, Andrea Marino2, Alessandra Di Nora1
1Postgraduate Training Programme in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
Infectious disease reports
|January 22, 2024
概括
在儿童中,COVID-19可能导致肌肉炎 (肌肉炎症),表现为小腿疼痛和肌酸激酶 (CK) 水平升高. 大多数儿科病例显示良性,自我限制的过程与支持性护理.
科学领域:
- 儿童传染病 儿童传染病
- 神经肌肉疾病 神经肌肉疾病
- 病毒性肌肉炎是一种病毒性肌肉炎.
背景情况:
- 新冠病毒病2019 (COVID-19) 主要影响呼吸系统,但可以表现为骨肌炎 (肌炎).
- 肌肉炎的特征是肌酸激酶 (CK) 的升高,在COVID-19的成年人中被认可,但其对儿科的影响不太了解.
- 了解儿童的COVID-19相关肌肉炎对于准确的诊断和管理至关重要.
研究的目的:
- 分析诊断为SARS-CoV-2感染的儿科患者肌肉炎的临床和实验室因素.
- 调查COVID-19后儿童肌肉炎的表现和结果.
- 在儿童COVID-19病例中确定实验室标记物和肌肉炎严重程度之间的潜在相关性.
主要方法:
- 这是一项回顾性研究,评估了十名确诊感染SARS-CoV-2和肌肉炎的儿科患者.
- 分析临床表现,包括发烧,小腿肌肉疼痛和步态异常.
- 实验室发现的审查,重点是肌激酶 (CK),血液尿素 (BUN) 和尿素/肌素比率 (UCR).
主要成果:
- 儿科患者呈现出发烧,小腿肌肉疼痛和异常的步态.
- 血清CK水平升高是一致的发现,与其他实验室异常一起.
- 在CK水平,BUN和尿素/肌素比率 (UCR) 之间观察到显著的相关性.
结论:
- 患有SARS-CoV-2感染的儿童肌肉炎通常遵循良性和自我限制的过程.
- 对CK,BUN和UCR等特定标记物的监测对于早期干预很重要.
- 需要进一步的研究,以充分了解病理生理机制,并优化儿童COVID-19相关肌肉炎的管理策略.
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