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在急性一氧化碳中毒患者中,高压氧气治疗的时间和延迟的神经后果之间的相关性

Sungwoo Choi¹, Sangun Nah¹, Sangsoo Han¹

¹Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea.

Diagnostics (Basel, Switzerland)

|January 22, 2024

概括

在一氧化碳 (CO) 中毒中,延迟神经系统 (DNS) 风险较高,最初的格拉斯哥昏迷量表 (GCS) 分数较低,延迟高压氧气疗法 (HBOT) 较高. 最佳的HBOT时间对于更好的患者结果至关重要.

科学领域:

神经学神经学
毒理学毒理学毒理学
紧急医疗紧急医疗

背景情况:

一氧化碳 (CO) 中毒是中毒的常见原因之一.
延迟的神经系统序列 (DNS) 显著影响患者的预后.
高压氧疗法 (HBOT) 是DNS的标准治疗方法,但最佳时间仍在争论中.

研究的目的:

调查CO中毒患者的HBOT最佳时间.
为了确定与CO暴露后DNS的发展相关的风险因素.

主要方法:

从2019年11月到2022年10月,对167名CO中毒患者进行前性研究.
分析最初的格拉斯哥昏迷量表 (GCS) 评分,CO暴露时间和HBOT的延迟时间.
确定截止值和估计接收器操作特征曲线 (AUC) 下的面积,用于风险预测.

主要成果:

在非DNS和DNS组之间观察到GCS得分,CO暴露时间,HBOT延迟,住院和肌酸酶水平的显著差异.
一个GCS得分≤9 (OR: 5.059) 和HBOT延迟≥200分钟 (OR: 18.971) 是DNS的显著风险因素.
预测DNS的AUC为0.8235.5,这是一个值.

结论:

初始GCS得分≤9和延迟到HBOT≥200分钟是CO中毒后DNS的显著预测指标.
这些发现表明,早期的HBOT干预可能对预防或减轻DNS的危害至关重要.

关键词:

一氧化碳中毒是一氧化碳中毒.认知功能障碍认知功能障碍决策树的树木高压氧气疗法 (hyperbaric oxygen therapy) 是一种高压氧气疗法.时间到治疗的时间.

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