双剂免疫疗法使用的多系统免疫相关不良事件
Yuchen Li1, Gregory Pond2, Elaine McWhirter2
1Department of Oncology, McMaster University, Hamilton, ON L8V 5C2, Canada.
Current oncology (Toronto, Ont.)
|January 22, 2024
概括
与多系统免疫相关的不良事件 (irAEs) 在接受伊皮利马布和尼沃马布的患者中很常见. 密切监测多个irAEs对于患者护理和医生教育至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 有限的数据存在于多系统免疫相关的不良事件 (irAEs) 从双 ipilimumab 和 nivolumab 治疗.
- 了解这些irrAEs对于治疗组合免疫疗法患者的管理至关重要.
研究的目的:
- 研究用伊皮利穆巴和尼沃卢穆巴治疗的癌症患者中多系统性irrAEs的发生率和特征.
- 为了比较患有多系统IRAE的患者和经历单个IRAE或没有IRAE的患者.
主要方法:
- 在Juravinski癌症中心 (2018-2022) 对123名癌症患者进行了回顾性队列研究.
- 收集的数据包括患者人口统计,癌症类型和irAEs.
- 进行了多变量逻辑和考克斯回归分析.
主要成果:
- 多系统IRE发生在40%的队列中.
- 黑色素瘤 (59%) 和细胞癌 (41%) 是最常见的癌症类型.
- 皮肤炎 (22%),大肠炎 (19%) 和肝炎 (17%) 是最常见的IRE.
结论:
- 在接受伊皮利慕巴和尼沃卢慕巴的患者中,多系统性IREEs很普遍.
- 医生教育和患者咨询关于潜在的多重irAEs是必不可少的.
- 建议对多个irAEs进行监测,以实现最佳的患者管理.
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