AG1® 在人类肠道微生物生态系统模拟器®模型中对肠道微生物结构和功能产生有利影响
Trevor O Kirby1, Philip A Sapp1, Jeremy R Townsend1,2
1Research, Nutrition, and Innovation, Athletic Greens International, Carson City, NV 89701, USA.
Current issues in molecular biology
|January 22, 2024
概括
基础营养补充剂AG1®在体外显著影响肠道微生物的组成和功能. 人体肠道微生物组的这些变化可能会导致有益的健康影响.
科学领域:
- 微生物学 微生物学
- 营养学科学 营养学科学
- 肠道微生物组研究研究
背景情况:
- 人的肠道微生物群在健康中起着至关重要的作用,是营养药物干预的目标.
- 了解补充剂如何影响肠道微生物群对于制定有效的健康策略至关重要.
研究的目的:
- 研究基础营养补充剂AG1®对人类肠道微生物群组成和功能的影响.
- 使用体外模型评估微生物群落结构和代谢途径的变化.
主要方法:
- 利用人类肠道微生物生态系统模拟器 (SHIME®) 模型进行体外消化,吸收和结肠模拟.
- 使用浅射枪,全基因组测序用于肠道微生物群的基因组分析.
- 分析了α多样性,β多样性,特定种类,功能异质性和代谢途径的变化.
主要成果:
- 没有观察到α多样性的显著变化.
- 在结构异质性上发现了显著的治疗和供体效应,以及相互作用,由八种丰富的细菌种群驱动.
- 社区的功能异质性也受到显著影响,有20个代谢途径显示丰富.
结论:
- 一剂AG1®的急性剂量在体外显然改变了肠道微生物的组成和功能.
- 这些发现表明,对人类肠道微生物群和宿主健康有潜在的有利影响.
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