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和添加三酸陶的抗微生物和细胞友好的特性

Dina V Deyneko^1,2, Vladimir N Lebedev¹, Katia Barbaro³

¹Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.

Biomimetics (Basel, Switzerland)

|January 22, 2024

概括

与和相配合的β-三酸 (β-TCP) 显示出作为骨替代品的前景. 这些材料具有抗菌性质,并且具有生物相容性,可以抑制微生物生长而不损害骨细胞.

科学领域:

生物材料科学生物材料科学
材料化学材料化学
整形外科的研究研究.

背景情况:

β-三酸 (β-TCP) 是一种常见的骨植入物材料.
用子对β-TCP进行兴奋剂可以赋予抗菌性质.
关于 (Ni) 和 (Co) 离子添加β-TCP的研究有限.

研究的目的:

为了合成和表征Ni-和Co-dopedβ-TCP固体溶液.
研究这些兴奋剂材料的结构性,生物相容性和抗菌性质.

主要方法:

高温固态反应用于合成Ca10.5-Ni(PO4) 7和Ca10.5-Co(PO4) 7.7.
结构分析以确定兴奋剂和点和相位稳定性.
在脂肪组织衍生的介质干细胞 (aMSC) 上进行MTT测定,以检测生物相容性.
对*C. albicans*,*E. coli*,*E. faecalis*,*S. aureus*和*P. aeruginosa*进行抗菌检测.

主要成果:

在β-TCP结构中观察到CO2+或Ni2+的兴奋剂和值为9.5mol/%.
纳入Ni和Coi离子稳定了β-TCP结构,并延迟了向α-TCP的相位过渡.
所有合成的样本都没有对aMSCs表现出细胞毒性作用,也没有抑制骨质分化.
Ni和Co-dopedβ-TCP对测试的微生物菌株表现出不同程度的抗菌活性.

结论:

和Co-dopedβ-TCP材料具有结构稳定性和生物相容性.
这些化酸盐具有显著的抗菌特性.
生物相容性和抗感染能力的结合使它们成为骨替代品应用的前景.

关键词:

这就是TCPTCPTCP.它是一种抗菌药物,具有抗菌作用.抗微生物药物是一种抗菌药物.骨植入物骨植入物骨植入物骨再生骨再生酸是一种酸.科巴尔特是什么意思科巴尔特是什么意思添加了酸三的化物.感染感染的感染.尼克尔尼克尔是什么意思替代的三酸替代了三酸.威特洛克的白色白色

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