新型牙科复合材料对Streptococcus mutans生物膜的影响
Rayan B Yaghmoor1, Mohammad Abdel-Hadi2, Haralampos Petridis2
1Department of Restorative Dentistry, College of Dental Medicine, Umm Al-Qura University, Makkah 24381, Saudi Arabia.
Journal of functional biomaterials
|January 22, 2024
概括
这项研究研究了添加抗菌聚氨酸 (PLS) 和重矿化单酸单酸盐 (MCPM) 到牙科复合材料. 更高的PLS水平降低了细菌生物膜,但降低了早期复合材料的强度.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 微生物学 微生物学
背景情况:
- 由于合金逐步淘汰和最小侵入性牙科,对高强度牙科复合材料的需求日益增加.
- 需要具有抗菌和重矿性质的材料来管理残留细菌并促进牙修复.
研究的目的:
- 量化抗菌聚氨酸 (PLS) 和重矿化单酸单 (MCPM) 对Streptococcus mutans生物膜的影响.
- 评估MCPM-PLS对牙科复合材料长时间强度的影响.
主要方法:
- 牙复合磁盘具有不同的MCPM-PLS填充剂百分比暴露于Streptococcus mutans生物膜.
- 生物膜特征 (生物质,pH,细菌活力,外聚糖,eDNA) 被量化.
- 复合材料的双轴屈曲强度在1周,1个月和1年浸水后进行了测试.
主要成果:
- 增加的PLS水平 (高达8%),线性减少的生物膜生物质,水溶性葡萄糖 (WSG) 和水不溶性葡萄糖 (WIG).
- 在较高的MCPM-PLS度 (12-6和16-8) 观察到细菌数量和细胞外DNA (eDNA) 的显著减少.
- 双倍的MCPM和PLS度分别降低了14%和19%的早期复合物强度,在以后的时间点的影响较小.
结论:
- 聚氨酸 (PLS) 有效地减少了Streptococcus mutans生物膜的形成,4%的PLS显示出减少生物质和葡萄糖的承诺.
- 需要更高的PLS度来显著减少细菌和eDNA减少,但会损害早期复合材料的强度.
- 优化MCPM-PLS含量对于平衡先进牙科复合材料中的抗菌,重矿化和机械性能至关重要.
关键词:
突变型链球菌 (Streptococcus mutans) 是一种流感菌.它是一种抗菌药物,具有抗菌作用.生物膜是一种生物膜.生物质的生物质是生物质.牙复合材料的使用外型多糖糖化物 (exo-polysaccharide) 是一种外型多糖化物细胞外DNA就是细胞外DNA.更多相关视频
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