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脏活检和免疫风湿学疾病:一项回顾性和观察性研究
Antonietta Gigante1, Rosario Cianci1, Annalisa Villa1
1Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Journal of personalized medicine
|January 22, 2024
概括
患有免疫风湿学疾病 (IRD) 的患者中,病很常见. 细胞活检有助于诊断各种病,指导针对性治疗诸如狼性炎和微观多炎等疾病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 类风湿病学 类风湿病学
- 病理学 病理学 病理学
背景情况:
- 脏干扰在免疫风湿学疾病 (IRD) 中很常见.
- 在IRD中发生的淋巴结膜炎 (GN) 复杂化了患者的管理.
- 了解IRD中脏疾病的范围至关重要.
研究的目的:
- 分析IRD患者脏疾病的频谱.
- 为了将病与年龄,功能,IRD病史和组织学相关联.
- 要区分与已知的IRD相关的脏干扰,与之无关的发现,以及 de novo IRD.
主要方法:
- 追溯分析了15年来来自成年患者的699个本地细胞活检.
- 根据IRD与活检结果的相关性,将患者分为三组.
- 跨群体的人口统计,临床和病理学数据的统计比较.
主要成果:
- 与IRD相关的脏干扰发生在25.2%的患者中.
- 狼性炎在第一组 (已知的IRD) 中占主导地位,年轻的患者和更多的女性.
- 微观多炎在第三组 (de novo IRD) 最常见,与急性炎综合征和急性损伤 (AKI) 相关.
结论:
- 免疫风湿学疾病呈现出各种临床和组织学脏表现.
- 活检对于准确诊断与IRD相关的病是必不可少的.
- 组织病理学发现为IRD中脏并发症的向治疗策略提供了指导.
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