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在患有脏损伤的ANCA相关血管炎患者中分析甲状腺功能
Wenhui Yu1, Yuelan Wang2, Liang Ma1
1Department of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.
Journal of personalized medicine
|January 22, 2024
概括
甲状腺功能障碍在患有脏疾病的抗中性子细胞质抗体相关血管炎 (AAV) 患者中很常见. 这种功能障碍增加了进展到透析依赖的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺功能障碍经常在患有脏疾病的患者中观察到.
- 抗中性细胞质抗体相关血管炎 (AAV) 可以影响功能.
- 在AAV中甲状腺功能和损伤之间的关系尚未得到充分证实.
研究的目的:
- 在患有AAV和损伤的患者中调查甲状腺功能.
- 在AAV患者中确定与甲状腺功能障碍相关的临床参数.
- 为了确定甲状腺功能障碍是否会影响AAV中病的进展.
主要方法:
- 对174名患有损的AAV患者进行了回顾性和前性研究.
- 收集并比较甲状腺功能正常和异常的患者之间的临床参数.
- 随访患者的中位数为68.6个月,以评估病进展.
主要成果:
- 在174名患者中,有150名 (86.2%) 患有甲状腺功能障碍,主要是甲状腺功能低下 (36.67%).
- 甲状腺功能障碍与不同的临床参数有关,并且患透析依赖症的风险更高.
- 在AAV患者中,晚年和白蛋白降低是甲状腺功能障碍的独立风险因素.
结论:
- 甲状腺功能障碍,特别是甲状腺功能低下,是AAV患者患有损伤的常见并发症.
- 在AAV患者中,甲状腺功能障碍与明显的临床特征和需要透析的可能性增加有关.
- 甲状腺功能障碍是透依赖性进展的重要危险因素,在损伤的AAV中.
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