失生性阴道微生物群通过阴道中的病原性分子诱导了早产级联
AbuZar Ansari1,2, Young-Ah You1, Gain Lee1,2
1Department of Obstetrics and Gynecology and Ewha Medical Research Institute, Ewha Womans University, Seoul 07985, Republic of Korea.
Metabolites
|January 22, 2024
概括
失生性阴道微生物群 (DVM) 与早产有关. 阴道中的致病细菌和特定分子与不良出生结果相关,突出显示DVM.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 生物化学 生物化学
背景情况:
- 失生性阴道微生物群 (DVM) 破坏阴道环境,影响pH,代谢物,蛋白质和细胞因子.
- 阴道微生物组在维持怀孕和影响分娩结果方面发挥着至关重要的作用.
研究的目的:
- 调查DVM对韩国孕妇阴道环境的影响.
- 确定出生结果的预测生物标志物,区分满期和早产.
主要方法:
- 宫性阴道液 (CVF) 样本从40名孕妇的第三个三个月内收集.
- 进行了微生物群分析,pH测量和向代谢物,TLR-4和细胞因子的量化.
- 样本被分为完整期分娩 (FTB) 和早产分娩 (PTB) 组.
主要成果:
- 过早分娩 (PTB) 组的阴道pH值 (>4.5) 与满期分娩 (FTB) 组 (>3.5) 相比显著更高.
- 在FTB中,有益的细菌如*Lactobacillus*和*Bifidobacterium*大量存在,而致病性细菌 (*Enterococcus faecalis*, *Staphylococcus*, *Prevotella*, *Ureaplasma parvum*, *Corynebacterium*) 在PTB中普遍存在.
- 乙酸,甲醇,TLR-4和TNF-α的升高水平与妊娠年龄和出生体重有负相关性.
结论:
- 大脑内膜异位症与早产有关,由致病分子介导.
- 阴道中的特定微生物和分子概况可以作为预测出生结果的生物标志物.
- 保持健康的阴道微生物群对于预防早产至关重要.
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