脂化刷-PEG聚合物作为低分子量肺药物递送平台
Lisa M Kaminskas1, Neville J Butcher1, Christopher N Subasic1
1School of Biomedical Sciences, University of Queensland, St Lucia, QLD, Australia.
Expert opinion on drug delivery
|January 22, 2024
概括
较小的脂化刷聚乙烯甘醇 (PEG) 聚合物显示出有希望的肺药理动力学和吸入药物输送的肺安全性. 这些新型系统为较大的纳米药物提供了替代品,具有增强膜上皮细胞吸收的潜力.
科学领域:
- 纳米医学是一种纳米医学.
- 聚合物化学 聚合物化学
- 肺部药物输送 肺部药物输送
背景情况:
- 纳米药物正在开发中,作为可吸入药物输送系统.
- 较小的聚合物系统,在肺部结合白蛋白,提供不同的实用性.
- 研究了脂化刷-PEG聚合物用于肺部应用.
研究的目的:
- 为了检查脂化刷-PEG聚合物的肺药动力学行为.
- 评估这些聚合物的肺清除模式和安全性.
- 为了研究透性,粘液透和细胞吸收.
主要方法:
- 肺部的药理动力学和肺部清除率在老鼠中进行了研究.
- 透性测试使用气泡上皮,小气道上皮和肺微血管内皮进行.
- 评估了粘液透和细胞吸收.
主要成果:
- 聚合物表现出类似的肺药理学和肺清除,在24小时内吸收率高达30%.
- 1C12-PEG在肺部显示出最高的安全性.
- 蛋白结合并没有显著影响膜运输,但C12结合的PEG显示在膜细胞中吸收增加.
结论:
- 脂化刷-PEG聚合物,特别是那些含有1C12脂的聚合物,代表了用于吸入药物输送的大型纳米材料的新替代品.
- 这些较小的系统为肺部药物输送提供了潜在的更安全和更有效的选择.
- 进一步研究它们在肺环境中的特定相互作用是有必要的.
更多相关视频
10:53Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
14.1K
09:41Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
Published on: February 25, 2021
23.1K
相关概念视频
Drug Delivery: Miscellaneous Routes
344
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
344
Inhaled Medications
271
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
271
