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激活转录因子3是一种新的生物标志物与清细胞癌进展的相关性

Zhicong Yang¹, Yongwang Hou², Jingqi Li¹

¹Central Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.

International journal of immunopathology and pharmacology

|January 22, 2024

概括

活性转录因子3 (ATF3) 在清细胞细胞癌 (ccRCC) 中降低,表明它可能是预后预测因素. 在CCRCC中,PAXIP1-AS2和OIP5-AS1/hsa-miR-221-3p/ATF3轴可以调节apoptosis.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

清细胞细胞癌 (ccRCC) 是一种具有高转移和复发率的侵袭性癌症.
迫切需要ccRCC的新型预后预测因子和治疗点.
激活转录因子3 (ATF3) 是一种具有双重致癌/抑制作用的基因,在ccRCC中尚未得到充分研究.

研究的目的:

调查ccRCC中ATF3的预后价值.
在ccRCC中识别ATF3的潜在上游调节者,包括microRNAs (miRNAs) 和长非编码RNAs (lncRNAs).
探索ATF3在ccRCC中的功能性作用,特别是与内质网膜 (ER) 应激和亡有关.

主要方法:

利用基于TCGA的在线数据库来分析ccRCC中的ATF3表达和患者预后.
使用StarBase数据库来预测上游的miRNAs和lncRNAs针对ATF3.
进行了基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 分析,以推断ATF3功能.
进行了相关性分析,以评估ATF3表达和ER压力之间的关系.

主要成果:

与正常组织相比,ccRCC组织中ATF3表达显著下降.
较低的ATF3表达与ccRCC患者的预后较差密切相关.
Hsa-miR-221-3p被确定为ATF3.3.的潜在miRNA调节器.
预测PAXIP1-AS2和OIP5-AS1是调节hsa-miR-221-3p/ATF3轴的关键上游 lncRNA.
ATF3 参与调节 ER 应激反应中的亡信号,ATF3 表达和 ER 应激之间存在正相关性.

结论:

在ccRCC中,ATF3的调控下降,并作为负预后生物标志物.
lncRNAs PAXIP1-AS2和OIP5-AS1,以及hsa-miR-221-3p/ATF3轴,是ccRCC中ER压力诱导的亡的潜在调节者.
这些发现突出了一个新的监管途径,对ccRCC有潜在的治疗影响.

关键词:

激活转录因子3的激活因子灭症 (apoptosis) 是一种死亡的过程.生物标志物生物标志物清细胞细胞癌是什么?细胞内膜网膜的压力应激

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